Supplements That Will Increase Testosterone

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The Human Effect Matrix summarizes human studies to tell you what effects Boron has on your body, how much evidence there is, and how strong these effects are.
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Outcome	Magnitude of effect ? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.	Consistency of research results ? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.	Notes
C-Reactive Protein (CRP)	Notable	Very High See all 5 studies	Most studies found notable reductions, with calcium fructoborate being the most supported form.
Cramps	Notable	- See study	One study in young women found a meaningful improvement in pain and duration of menstrual cramps.
Erythrocyte Sedimentation Rate	Notable	Very High See 2 studies	There was a notable reduction with low, medium, or high doses in people with osteoarthritis. and rheumatoid arthritis.
Interleukin 1-beta	Notable	- See study	There was a notable reduction in one study in healthy participants, with no notable difference between 1.5 mg and 3 mg of calcium fructoborate.
Interleukin 6	Notable	Very High See 2 studies	Notable reductions have been found in people with rheumatoid arthritis and healthy participants.
N-terminal Prohormone of Brain Natriuretic Peptide	Notable	- See study	There was a notable reduction in one study, when taken on its own or combined with resveratrol compared with control and resveratrol alone.
PMS	Notable	- See study	One study in young women found a modest improvement in pain and duration of menstrual cramps. No other symptoms of PMS have been evaluated.
Pain	Notable	- See study	There was a notable reduction in knee pain in one study on people with knee discomfort.
Symptoms of Osteoarthritis	Notable	- See study	There was a notable reduction in overall symptoms in a study on people with knee discomfort but who hasn't necessarily been diagnosed with osteoarthritis of the knee.
Symptoms of Rheumatoid Arthritis	Notable	- See study	There was a notable reduction from sodium tetraborate and calcium fructoborate in one small study. Calcium fructoborate looked somewhat more potent.
TNF-Alpha	Notable	- See study	There was a notable reduction in one study on people with rheumatoid arthritis. Calcium fructoborate was more effective than sodium tetraborate.
Estrogen	Minor	Low See all 3 studies	Appears to influence estrogen, seems unreliable in its mechanisms and is likely context dependent. Both increases and decreases have been noted
Fibrinogen	Minor	- See study	There was somewhat of a reduction in people with osteoarthritis in one study.
Free Testosterone	Minor	Very High See 2 studies	Appears to be somewhat effective, but requires some more robust trials
Homocysteine	Minor	- See study	There was a small decrease in healthy participants in one study.
Inflammation	Minor	- See study	Some influence on typically inflammatory cytokines, practical relevance of these changes unknown
Interleukin 1-alpha	Minor	- See study	Calcium fructoborate led to a notable reduction in one study in participants with rheumatoid arthritis, while calcium tetraborate only led to a small reduction.
Kidney Stones	Minor	- See study	Appears effective, but no comparison to a reference drug nor control group thus far
Liver Enzymes	Minor	- See study	One crossover study found a small increase in alkaline phosphatase when boron was taken second, but not when taken first. More research is needed to verify this.
Low-density lipoprotein (LDL)	Minor	High See all 3 studies	Somewhat of a reduction in participants with high LDL has been noted in 3 studies.
Lymphocyte Count	Minor	- See study	A small reduction was noted in one study. More studies are needed to verify this.
Monocyte Chemoattractant Protein-1	Minor	- See study	There was a reduction in one study on healthy participants. 3 mg of boron from calcium fructoborate was modestly more effective than 1.5 mg.
Serum Magnesium	Minor	- See study	There was somewhat of an increase in one study from 3 mg of chelates of citrate, aspartate, and glycinate.
Serum T3	Minor	- See study	There was both an increase and a decrease in a crossover trial when boron was taken first or second.
Serum T4	Minor	- See study	There was both a small increase and a decrease in a crossover study depending on whether boron was taken first or second.
Testosterone	Minor	High See all 3 studies	There appears to be somewhat of an interaction with boron and testosterone in both genders, but it is seemingly unreliable
Thyroid-Stimulating Hormone	Minor	- See study	While not statistically significant, boron saw a small increase when taken first in a crossover trial, but not when taken second.
Total cholesterol	Minor	Very High See all 3 studies	Studies have generally found a small reduction in people with elevated levels.
White Blood Cell Count	Minor	- See study	There was somewhat of an increase in one study of peri-menopausal women. More research is needed to verify this.
Blood glucose	-	- See study	There was no effect in participants with healthy blood sugar levels in one study.
Body Fat	-	- See study	No apparent effect in one study of normal weight males.
Cortisol	-	- See study	No significant effect on cortisol has been noted with supplemental boron
DHT	-	- See study	No significant influences on serum DHT noted
Follicle-Stimulating Hormone	-	- See study	There was an increase in one crossover study when it was taken second, but not when it was taken first.
High-density lipoprotein (HDL)	-	High See all 3 studies	Studies don't suggest a meaningful effect overall.
Lean Mass	-	- See study	No apparent effect in one study.
Plasma Calcium	-	- See study	No apparent effect in one study from 3 mg of chelates of citrate, aspartate, and glycinate.
Strength	-	- See study	No apparent effect on 1-rep max squats and benchpress in men involved in a training program.
Triglycerides	-	High See all 3 studies	The studies don't consistently suggest a meaningful effect